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nagZ [2017-8-11 16:0:3]
function
cell wall recycling
product
N-acetylglucosaminidase
Genomic Context
categories
[category|SW 1|Cellular processes] → [category|SW 1.1|Cell envelope and cell division] → [category|SW 1.1.3|Cell wall degradation/ turnover] → [category|SW 1.1.3.3|Utilization of cell wall components]Gene
Coordinates
186,452 → 188,380
Phenotypes of a mutant
increased autolysis [Pubmed|20400549]The protein
Catalyzed reaction/ biological activity
cleaves muropeptides derived from peptidoglycan, but not peptidoglycan itself [Pubmed|20400549]Protein family
glycosyl hydrolase 3 family (according to Swiss-Prot)Structure
[PDB|3BMX] [Pubmed|20826810][SW|Localization]
secreted (with signal peptide), remains to some extent cell wall-associated [Pubmed|20400549]Additional information
The gene is mis-annotated in KEGG as an ortholog of beta-N-acetylhexosaminidase EC 3.2.1.52. It is marked in MetaCyc as “similar to beta-hexosaminidase”. No EC annotation is available in Swiss-ProtSwiss-Prot.supporting the annotation is available. [Pubmed|19935659]Expression and Regulation
Operons
genes
[gene|0B1F43F43A4DC1574A153DBFBAA5D0A1855F9B61|murQ]-[gene|125872506C400CB6B3DAEA8B5130B064DFBA4494|murR]-[gene|178D5E2AA1225FE909E6F2B63B3595F5ABB8E7A2|murP]-[gene|DEACFD435DB01C4B3ADEF397BEE08E2E7C7FCC36|amiE]-[gene|A5D4BF262BD365DCEBA9358C8DB295E605DE4D84|nagZ]-[gene|005D37F34CA3D6891F7D8FF7A2AFA1CBCB556FFE|ybbC]
description
[Pubmed|22383849]
regulatory mechanism
[protein|125872506C400CB6B3DAEA8B5130B064DFBA4494|MurR]: repression, [pubmed|30038046], in [regulon|125872506C400CB6B3DAEA8B5130B064DFBA4494|MurR regulon]regulation
expressed in late exponential and early stationary phase [Pubmed|20400549]view in new tabBiological materials
Mutant
available in [SW|Christoph Mayer]'s lab [Pubmed|20400549]References
10627040,20400549,4628806,4196675,22383849,26963691 
